Cisplatin hearing loss thesis

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August undefined, 2024

WebJun 21, 2024 · Hearing loss of grade 1 or higher occurred in 18 of 55 children (33%) in the cisplatin–sodium thiosulfate group, as compared with 29 of 46 (63%) in the cisplatin-alone group, indicating a 48% ... WebNoise-induced hearing loss (NIHL) is a complex disease which might be caused by interactions between environmental and genetic factors. Noise is the best-known and one of the most studied environmental factors causing hearing loss.

High-dose cisplatin treatment: hearing loss and plasma

http://etds.lib.ncku.edu.tw/etdservice/detail?n=20&etdun3=U0026-0808201316053000&etdun4=U0026-2308201215132500&etdun7=U0026-2607201113092800&etdun9=U0026-0108201016204100&etdun10=U0026-2706201001360500&etdun11=U0026-2601201019334400&etdun12=U0026-2408201016131400&etdun18=U0026-0812200911435655&etdun19=U0026-0812200911293383&etdun20=U0026-0812200911134013 WebAug 25, 2024 · Platinum containing chemotherapeutic agents are associated with cochleotoxicity, characterized by high frequency hearing loss. Cisplatin and related … how does methylmercury form

Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity

WebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge that all patients should be tested routinely. WebApr 1, 2011 · As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. WebCisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy … photo of gorbachev

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A study of cisplatin chemotherapy and hearing loss

Web20 hours ago · The drug, which is Fennec's sole product, is intended to prevent hearing loss in pediatric cancer patients treated with cisplatin chemotherapy. WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk … photo of gopal krishna gokhaleWebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … photo of google earth

"WebJan 1, 2024 · Atorvastatin use significantly reduces the odds of a clinically meaningful cisplatin-induced hearing loss. An analysis of the incidence of a CTCAE-defined hearing loss due to cisplatin therapy in the full cohort and key subgroups is shown. For the full cohort and the subject subgroups, the difference in the incidence (% of ears) and 95% CI … " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

Mechanisms of Aminoglycoside- and Cisplatin-Induced …

WebJan 26, 2024 · A New Approach to Researching Cisplatin-Induced Hearing Loss. The new study differs from previous research because it is a comprehensive look at the pharmacokinetics, or concentration, of the … WebMar 26, 2024 · The severity of cisplatin-related ototoxicity is associated with age and the cumulative dose received: the younger the child and the higher the total dose, the more severe the hearing loss may be. The spectrum of hearing loss varies from mild to moderate high tone hearing loss, to profound loss across the hearing range and …

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WebJun 1, 2024 · Hearing loss likely occurs in all cancers that are treated with cisplatin. Cisplatin is the most ototoxic drug in clinical use. It also happens to be a fantastic … Webhearing loss observed is typically irreversible, progressive, bilateral, high-frequency sensorineural hearing loss associated with tinnitus. At present there is no approved …

WebCisplatin-Induced Hearing Loss Childhood Cancer Hearing Loss Patient Focused Drug Development (PFDD) Meeting The pediatric patient population with chemotherapy … WebJul 13, 2024 · “Around 60% to 80% of kids who get cisplatin have significant hearing loss,” Dr. Neuwelt explained. The impact of that hearing loss can be profound, he continued, including greatly increasing the risk …

WebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. … WebImproved survival from childhood cancer has been achieved at the cost of long-term comorbidities that reduce quality of life. The chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced hearing loss, a debilitating and permanent late …

WebNov 21, 2024 · Cisplatin chemotherapy causes permanent hearing loss in 40-80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetic …

WebApr 26, 2024 · 1 In a recent study, most patients (388 of 488, 80%) had a hearing loss of at least 20 dB and 40% suffered from tinnitus. 2 Sixty-three to 77% of children 3 4 suffer permanent sensorineural hearing loss from cisplatin chemotherapy. Cisplatin primarily affects the high frequencies in both ears and is permanent. photo of goodluck ebele jonathanWebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge … photo of gough whitlam and vincent lingiariWebSynthese und Charakterisierung von neuen Dicobalthexacarbonyl-Komplexen als Cycl... 9 Referenzen [1] Titelblatt photo of goutWebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … how does methotrexate work for psoriasisWebJan 1, 2024 · Cisplatin-induced hearing loss is permanent, and there are currently no FDA-approved therapies to reduce or prevent cisplatin ototoxicity. Here we explore the … how does methylparaben workWebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic … photo of gospel singer lee williamsWebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the etiology … how does methylphenidate help with adhd