Fbxw5 cancer
WebAug 9, 2024 · SCF Fbxw5 -dependent polyubiquitylation targets MCAK for degradation during G 2 phase, while post-mitotic degradation is driven by the APC/C ligase. Defects in MCAK ubiquitylation and degradation cause its accumulation at basal bodies during the subsequent G 1 /G 0 phase, impairing ciliogenesis. WebJun 17, 2024 · The present study investigates the role of FBXW5 in tumorigenesis and metastasis, as well as the regulation of key signaling pathways in gastric cancer; using …
Fbxw5 cancer
Did you know?
WebExpression of FBXW5 (DKFZP434B205, Fbw5, MGC20962) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from. Read ... Web研究背景： 癌症是导致死亡的一个重要原因，也是提高预期寿命和质量的一大障碍。大量的e3连接酶因其特异性底物识别的特点而广泛参与癌症相关过程。f-box和wd重复域包含(fbxw)族的scf e3复合物有10个成员，负责参与细胞周期调节和肿瘤发生的底物蛋白的泛素化 …
WebExpression of FBXW5 (DKFZP434B205, Fbw5, MGC20962) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. WebApr 10, 2024 · Gastric cancer (GC) is a common disease worldwide. Due to its high incidence and mortality, GC is the fourth most common malignancy and the fourth main cause of cancer-related death globally 1,2. ...
WebShowing subcellular location of FBXW5 (DKFZP434B205, Fbw5, MGC20962). We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again. FBXW5. ... Cancer Prognosis. Cancer ... WebDec 1, 2024 · Despite its known function as a component of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex, the role of FBXW5 in gastric cancer tumorigenesis and metastasis has not been investigated.
WebCRL4A-FBXW5–mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth Tai Young Kima,b, Sarah Jackson a,c, Yue Xiong , Timothy G. Whitsettd, Janine R. Lobelloe, Glen J. Weissd,f, Nhan Le Trand, Yung-Jue Bangg, and Channing J. Dera,b,1 aLineberger Comprehensive … kjf property maintenanceWebJul 3, 2011 · The PLK4 kinase and centrosomal protein HsSAS-6 both regulate centrosome duplication. PLK4 negatively controls an FBXW5-containing ubiquitin ligase, which targets SAS-6 for destruction to restrict ... kjf musicWeb人细胞角蛋白18-m65（ck 18-m65）elisa试剂盒 ；英文名称： ck 18-m65 elisa kit ；实验名称： 人细胞角蛋白18-m65（ck 18-m65）elisa试剂盒 ；实验别名： 人细胞角蛋白18-m65（ck 18-m65）elisa试剂盒 48t/96t ；规格： 48t/96t 报价 人细胞角蛋白18-m65（ck 18-m65）elisa试剂盒实验目的：本试剂盒仅供研究使用 ，用于 用于测定 ... kjf twitterWebof FBXW5 mRNA and protein expressions (Figure S1A,B). Subsequently, MKN1 was used as an in-vitro model, considering its high mRNA expression of FBXW5. FBXW5 expression was knocked down in MKN1 cells using FBXW5 targeted siRNAs to investigate the role of FBXW5 in gastric cancer cell proliferation (Figure1A,B). kjf group p/lWebDec 14, 2024 · FBXW5/9/12 were overexpressed in most cancers, however, FBXW11 expression in pan-cancer was opposite. Notedly, FBXW7, as a tumor suppressor, was highly expressed in six cancers (CHOL, KIRC, … kjey travels and toursWebFeb 19, 2014 · Purpose FBXW7 is a tumor suppressor gene responsible for the degradation of several proto-oncogenes. Preclinical data suggest that FBXW7 mutations sensitize … kjf appraisals and auctionsWebFBXW5 INFORMATION. Proteini. Full gene name according to HGNC. F-box and WD repeat domain containing 5. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. FBXW5 (DKFZP434B205, Fbw5, MGC20962) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). kjf thurgau