Stathmin 1
WebApr 6, 2024 · STATHMIN-2 (STMN2) is a well-validated protein important for neural repair and axonal stability, the expression of which is significantly decreased in nearly all ALS patients. Also known as SCG-10, STMN2 is a protein essential for the stabilization of microtubules which form an important component of the cytoskeleton of cells and axons. WebPurified recombinant Human Stathmin 2 protein. 反应种属: Human. 宿主来源: 实验应用: SDS-PAGE. 靶标/特异性: 同种型: 推荐稀释度: ... 表达系统: E.coli. 阳性对照: 保存温度: Store …
Stathmin 1
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WebSep 20, 2024 · Stathmin-1 has been reported to interact with heat shock protein 27 (HSP27), which is an inhibitor of cyclin-dependent kinases and can promote the proliferation of … WebApr 12, 2024 · STATHMIN-2 has been shown to be highly expressed in human motor neurons, the cells that primarily degenerate in ALS. ANQUR, a multi-center, randomized, double-blind, placebo-controlled multiple ascending dose study, is the first to assess a therapy that rescues STMN2 expression in patients with ALS.
WebStathmin 1, also known as oncoprotein 18 (Op18), p17, p18, p19, 19K, LAP 18, and metablastin, is a ubiquitous, highly conserved 18-kDa cytosolic phosphoprotein . It is … WebStathmin 1 is composed of 149 amino acids organized into four domains (I–IV) as defined by limited proteolysis. The core region (amino acids 42–126) is the minimum fragment required for tubulin interaction with the additional requirement of either an N- …
WebStathmin 1 (STMN1) is a critical protein involved in microtubule polymerization and is necessary for survival of cancer cells. This editorial describes the role of targeted … WebNov 27, 2024 · Stathmin 1 (STMN1) is a microtubule-destabilizing protein highly expressed in hematological malignancies and involved in proliferation and differentiation. Although a …
WebJan 23, 2007 · Stathmin Gene STMN1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 149 Protein existence Evidence at protein level …
Stathmin is a ubiquitous phosphorylated protein which makes it act as an intracellular relay for diverse regulatory pathways, functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [11] and in response to extracellular … See more Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene. Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell See more Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), … See more Stathmin interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex. One mole of stathmin … See more Mice without stathmin have deficiency in innate and learned fear. Stathmin−/− females do not assess threats well, leading to lack of … See more The function of Stathmin is to regulate the cytoskeleton of the cell. The cytoskeleton is made up of long hollow cylinders named microtubules. These microtubules are made up of alpha … See more Stathmin's role in regulation of the cell cycle causes it to be an oncoprotein named oncoprotein 18 (op18). Stathmin (aka op18) can cause … See more • Sobel A (August 1991). "Stathmin: a relay phosphoprotein for multiple signal transduction?". Trends in Biochemical Sciences. 16 (8): 301–5. doi:10.1016/0968-0004(91)90123-D. PMID 1957351. • Steinmetz MO (May 2007). "Structure and … See more crossword bitterly pungentWebStathmin 1 (STMN1), also known as leukemia-associated phosphoprotein p18, metablastin, oncoprotein 18 (op18), phosphoprotein p19, prosolin, protein Pr22, and pp17, is a member … crossword bk after proverbshttp://www.neobioscience.com/prod_view.aspx?TypeId=409&Id=2337947&FId=t3:409:3 crossword blackWebJan 13, 2024 · The fear gene stathmin plays an important role in regulating fear memory. However, whether the fear gene stathmin is related to fear memory loop anomalies caused by PTSD is unclear. A single-prolonged stress (SPS) rat model of PTSD was constructed. Wistar rats were randomly divided into 5 groups: the control group, SPS 1-day group, SPS … crossword blackberry stemWebStathmin 1 (STMN1) is a candidate oncogene whose activity is influenced by p53, p27Kip1 (p27), and PI3K/Akt pathway activation. As a microtubule destabilizing protein, STMN1 … crossword blackbirdWebHigh-performance liquid chromatography and 2D gel electrophoresis analysis, coupled with mass spectrometry, revealed that stathmin 1 is strongly phosphorylated within only 5 min of exposure to PACAP. Western blot experiments confirmed that PACAP induced a robust phosphorylation of stathmin 1 in a time-dependent manner. On the... More Keywords crossword blackhead removerWebIntroduction: Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the downstream target of many signal transduction pathways. Several studies then indicated … crossword black dog singer parks